8)Sonic and Knuckles from Sonic

7)Gordan Freeman and Alyx Vance from Half-Life

6)Banjo and Kazoonie from Banjo Kazoonie

5)Soild Snake and Otacon from MGS

4) Jak and Daxter

3)Rachet and Clank

2)Dk and Diddly

1)Mario and Luigi

edit: ya i like knuckles more

i'd say sonic and knuckles is more of a partnership than sonic and tails

 

1) Mario & Luigi

2) Sonic & Knuckles

3) Ratchet & Clank

4) Snake & Otacon

5) Jak & Daxter

6) DK & Diddy

 

never heard of the others

Edit